This best practice guide concerns various aspects related to infusion technology and is developed for clinical users such as nurses and physicians. This guide is put together based on a literature research and on lessons learned from MeDD and focuses on critical drug delivery applications. Here, critical is defined as those applications that require an accuracy of 95% or better. The technical aspects covered in this guide are therefore mostly related to how this accuracy can be ensured. Because the focus is at high accuracy applications, only syringe pumps are considered.